Follistatin is commonly referred to as an activin-binding protein. Its primary goal is to inhibit myostatin, neutralize various TGF-beta compounds that are in charge of promoting growth and development, and improve homeostasis and regulation of the immune system. Follistatin-344 (FST-344) is an analogue of the naturally occurring peptide, follistatin, synthesized through the splicing of follistatin mRNA.The splicing of follistatin leads to two different isoforms FST-344 and FST-317 these then undergo further peptide cleavage to produce the variants FST-315 and FST-288, respectively. Many studies have been conducted determining the efficacy of myostatin inhibition of each follistatin isoform and how they relate to the degree of improvement of muscle growth [1].
Main Research Findings
1) Treatment with follistatin led to a dramatic increase in muscle weight of transgenic mice. This allowed researchers to conclude that follistatin is capable of effectively inhibiting myostatin, which ultimately resulted in significant muscle growth.
2) The results of this study determined that a single injection of FST-344 effectively inhibits myostatin in a way that promotes the enhancement of muscle size and strength. FST-344 was also successful at reversing degeneration and improving muscular function in mdx animals with induced DMD.
3) The research team of Rose et. Al concluded that treatment with follistatin enhances gross motor function and muscle size in rats exhibiting spinal muscular atrophy (SMA).
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